相关实验视频
Updated: Feb 5, 2026

08:39
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
5.5K
超声响应的Mn/Se-纳米酶作为膀癌免疫疗法的PANoptosis启动剂
Yisheng Yin1, Zhenliang Qin1, Hui Zhou1
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Advanced healthcare materials
|February 4, 2026
概括
一种新的纳米酶疗法激活了STING信号和PANoptosis,增强了膀癌的抗瘤免疫力. 这种超声响应治疗促进T细胞反应,改善瘤控制,提供了一个有前途的纳米免疫疗法策略.
科学领域:
- 生物医学工程 生物医学工程
- 癌症研究 癌症研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 膀癌带来了严重的复发和死亡率挑战.
- 目前的手术和化疗等治疗方法都有局限性.
- 免疫检查点抑制剂 (ICI) 由于瘤免疫透不良,其疗效有限.
研究的目的:
- 开发一种超声响应的纳米酶,用于膀癌治疗.
- 为了激活STING信号传递和PANoptosis,增强抗瘤免疫力.
- 为了研究纳米酶的潜力与PD-1阻断结合.
主要方法:
- 开发一个超声响应的Mn/Se-NE@FCS纳米酶.
- 在小鼠膀癌模型中的体外和体内研究.
- 评估STING和PANoptosis激活,ROS产生,线粒体功能障碍和免疫细胞死亡 (ICD).
- 评估免疫细胞透 (树突细胞,CD8+T细胞) 和记忆T细胞扩张.
- 对瘤微环境调节的组织学和流细胞计分析.
主要成果:
- 纳米酶有效地激活了STING信号传递和PANoptosis,诱导了多途径细胞死亡.
- 治疗增强了ROS的产生,线粒体功能障碍和ICD.
- 纳米酶治疗促进了树突细胞的成熟,并增加了CD8+ T细胞的透.
- 观察到优异的瘤控制,与PD-1阻断相结合时具有显著的协同作用.
- 该治疗成功地重塑了瘤微环境,推动了免疫激活和T细胞启动.
结论:
- 开发的超声响应纳米酶是膀癌纳米免疫治疗的有希望的策略.
- 双重激活STING和PANoptosis有效诱导瘤细胞死亡和全身免疫力.
- 这种方法提供了一种新的方法来克服当前膀癌治疗的局限性,并增强抗瘤反应.
相关概念视频
Initiation of Translation
39.0K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Initiation of Translation
8.1K
8.1K
Tumor Immunotherapy
1.9K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Transcription Initiation
21.1K
Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
The promoters and enhancers and their accessory proteins allow tight regulation of...
21.1K
Urinary Bladder
3.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.5K
Ultrasound II: Endoscopic Ultrasound and FibroScan
702
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
702

