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Updated: Feb 5, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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HBE-843是一种新的,强大的,有选择性的EGFR向PROTAC,用于治疗非小细胞肺癌

Mohammad Hassan Baig1, Chang Joong Kim1, Nale Sagar Dattatraya1

  • 1BNJ Biopharma, Incheon, Republic of Korea.

Archiv der Pharmazie
|February 4, 2026
PubMed
概括

一种新的EGFR PROTAC,HBE-843,有效地降解了包括C797S在内的EGFR突变,克服了非小细胞肺癌中针对性治疗的耐药性. 这种有前途的化合物在临床前模型中显示出显著的瘤生长抑制.

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