第一个东南亚的Terbium-161 PSMA治疗转移性割抵抗性前列腺癌 (mCRPC) 的经验:定量成像和剂量计方法
Sasithorn Amnuaywattakorn1, Putthiporn Charoenphun1, Touch Ativitavas2
1Mahidol University Faculty of Medicine Ramathibodi Hospital, Department of Diagnostic and Therapeutic Radiology, Division of Nuclear Medicine, Thailand, Bangkok.
Molecular imaging and radionuclide therapy
|February 4, 2026
概括
-161 (Tb-161) PSMA疗法在前列腺癌治疗中比路铁-177 (Lu-177) PSMA具有潜在的优势. 本案例研究详细介绍了东南亚第一个Tb-161 PSMA治疗.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 放射性药物疗法是一种放射性药物疗法.
背景情况:
- 前列腺特异性膜抗原 (PSMA) 向的放射性核素疗法已用于转移性割抵抗性前列腺癌.
- 177 (177Lu) PSMA疗法显示出临床益处.
- -161 (161Tb) PSMA 是一种新兴的超声波剂,由于结合的β和Auger电子排放,它具有潜在的优势.
研究的目的:
- 报告161Tb-PSMA治疗在泰国和东南亚的首次临床应用.
- 描述一个患有转移性割抵抗性前列腺癌,在177Lu-PSMA治疗中进展的患者的治疗方法.
- 突出实施量化成像和剂量计,以实现个性化治疗规划.
主要方法:
- 161Tb-PSMA治疗的临床管理.
- 实施定量成像协议.
- 单光子发射计算机断层扫描/计算机断层扫描 (SPECT/CT) 校准.
- 基于voxel的剂量计用于估计吸收剂量.
主要成果:
- 在177Lu-PSMA治疗后,161Tb-PSMA在患有进展性疾病的患者中成功临床应用.
- 对量化成像和剂量计方案的演示,以实现个性化治疗.
- 泰国和东南亚的第一个161Tb-PSMA治疗案例.
结论:
- 161Tb-PSMA代表了前列腺癌治疗治疗药物的有希望的进展.
- 定量成像和剂量测量对于优化161Tb-PSMA治疗计划至关重要.
- 这个案例为该地区进一步研究和临床使用161Tb-PSMA奠定了基础.
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