疫苗开发的全面审查:从传统平台到信使RNA (mRNA) 技术
Bhupendra Pawar1, Subha Loganathan2, Karthik Mukkatira Belliappa3
1Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.
Cureus
|February 4, 2026
概括
现代疫苗开发,由COVID-19加速,从传统转向新的平台,如信使RNA (mRNA) 疫苗. 这些新技术为未来的流行病准备提供了更快,更安全,更公平的免疫策略.
科学领域:
- 疫苗学和免疫学 疫苗学和免疫学
- 传染病研究传染病研究.
- 生物技术和制药发展
背景情况:
- 传统的疫苗平台 (无活化,活衰减,重组) 在可扩展性,开发时间和冷链要求方面面临限制.
- 随着COVID-19的爆发,人们越来越需要敏捷和适应性的疫苗技术来应对新出现的传染病.
- 转向新型疫苗模式的转变是显而易见的,这是由全球卫生危机的紧迫性驱动的.
研究的目的:
- 根据免疫性,安全性,有效性和稳定性进行叙事审查,比较现代疫苗接种平台.
- 分析新型疫苗在传染病治疗和其他应用方面的潜力.
- 为未来的创新和政策协调提供信息,以加强全球流行病防控和免疫战略.
主要方法:
- 2018年至2025年间发表的免疫学,监管学和临床文献的叙述综合.
- 现代疫苗平台的结构性比较,重点关注关键绩效指标.
- 包含机制性见解和实施障碍,以便进行全面分析.
主要成果:
- 基于信使RNA (mRNA) 的疫苗表现出强大的免疫性和现实世界的疗效.
- 在不同的疫苗平台上,安全性概况各不相同.
- 新的模式显示出治疗传染病和更广泛应用的潜力.
结论:
- 使者RNA (mRNA) 技术显著改变了疫苗学,使得免疫接种更快,更安全,更公平.
- 解决监管灵活性,公平分配和药物监管对于有效的全球免疫接种至关重要.
- 一个渐进的,以公平为基础的范式对于21世纪的疫情防控和免疫战略至关重要.
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