特兰克萨姆酸与部骨折手术中术后输血率降低有关:一项回顾性研究
Ellen Geary1, Gerard A Sheridan2, Kealan Blake3
1Orthopaedic Surgery, St. Vincent's University Hospital, Dublin, IRL.
Cureus
|February 4, 2026
概括
在关节骨折手术中使用外科手术期间的松酸 (TXA) 减少了对输血的需要,并改善了手术后的血红蛋白水平. 这项研究发现,随着TXA的使用,静脉血栓栓塞 (VTE) 事件的风险没有增加.
科学领域:
- 整形外科手术 整形外科手术
- 创伤外科 手术 创伤外科
- 麻醉学 麻醉学
背景情况:
- 输血在关节骨折手术中很常见,并带有潜在的不良影响.
- 减少异构血液输血是临床优先事项.
- 特兰胺酸 (TXA) 是一种抗纤维解质剂,可以减少外科手术期间的血液损失.
研究的目的:
- 评估外科手术期间的松酸 (TXA) 对骨骨折患者的输血率和血栓栓事件的影响.
- 评估TXA对术后血红蛋白水平的影响.
主要方法:
- 单中心,回顾性队列研究.
- 包括2019年8月1日至2020年8月1日期间接受关节骨折手术的患者.
- 对接受TXA和不接受TXA的患者之间的结果进行比较.
主要成果:
- TXA的使用显著与手术后输血率的降低有关 (RR 0.64,p = 0.022).
- 在TXA组中,手术后的血红蛋白水平显著更高 (107 g/L vs 101 g/L,p = 0.0183).
- 在使用TXA时,没有观察到深静脉血栓症 (DVT) 或肺栓塞 (PE) 的统计显著增加 (p = 0.242).
结论:
- 在关节骨折手术中进行手术内TXA的使用减少了手术后输血的需求,并改善了血红蛋白水平.
- 在这个患者群体中,TXA似乎不会增加静脉血栓塞栓症 (VTE) 的风险.
- 需要进一步的研究来优化TXA剂量,输送和关节骨折手术的时间.
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