在一级学术创伤中心进行一年的低滴度全血复苏
David A Leon1,2, Christopher M Wend3, Zakk Arciaga3
1Department of Anesthesiology and Pain Medicine, University of California Davis School of Medicine, Sacramento, USA.
Cureus
|February 4, 2026
概括
低位数O阳性全血 (LTOWB) 复苏对于经历大规模出血的创伤患者来说是安全和可行的. 这项研究在81名接受LTOWB治疗的成年创伤患者中没有发现危及生命的输血反应.
科学领域:
- 紧急医疗 紧急医疗
- 创伤外科 手术 创伤外科
- 输血医学 输血医学
背景情况:
- 出血性休克是创伤患者的主要可预防的死亡原因.
- 全血复苏对管理大量出血充满希望,特别是在军事环境中.
- 民用创伤中心越来越多地采用全血复苏方案.
研究的目的:
- 为成人创伤患者描述实施低位数O阳性全血 (LTOWB) 协议的初始经验和安全性.
- 为了评估LTOWB管理后的医院死亡率和输血反应.
- 评估LTOWB在民用城市创伤中心的可行性.
主要方法:
- 在12个月的时间内 (2022年12月至2023年12月) 接受LTOWB治疗的成年创伤患者的单中心描述性分析.
- 纳入标准侧重于在初始复苏期间接受LTOWB的成年患者,不包括特定的患者群体 (例如儿科,无脉).
- 收集的数据包括LTOWB单位,输血的总血液成分,住院死亡率和输血反应.
主要成果:
- 81名成年患者接受了LTOWB,中位数为2个单位.
- 整体的住院死亡率为23.5%.
- 在LTOWB的24小时内没有观察到危及生命的输血反应.
结论:
- 在城市创伤中心实施LTOWB协议是安全的,并且可以在创伤患者的初始复苏中进行出血性休克.
- 该研究表明没有显著的输血不良反应,支持LTOWB的安全性.
- 需要进行未来的研究,以阐明LTOWB对特定患者亚组和整体生存结果的影响,并考虑潜在的生存偏差.
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