装有塞法列辛的聚乙烯醇/氧化石墨烯薄膜作为抗菌性伤口敷料
Soroush Barkhordari1, Soroush Yousefi2, Safa Momeni Badeleh3
1Department of Organic Chemistry, Faculty Chemistry, Alzahra University Tehran 19938-93973 Iran br_soroush@yahoo.com +989121300969.
RSC advances
|February 4, 2026
概括
生物降解的聚乙烯醇/氧化石墨烯薄膜被开发用于局部的塞法列辛输送. 这些片显示出有前途的抗菌活性和受控的药物释放,表明伤口愈合应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 局部药物递送系统需要具有可控释放性质的材料.
- 可生物降解的聚合物为伤口愈合应用提供了优势.
- 加入氧化石墨烯可以增强材料的性能.
研究的目的:
- 开发和描述可生物降解的聚乙烯醇/氧化石墨烯薄膜,用于局部输送塞法列辛.
- 为了研究药物加载,释放动力学和开发的膜的抗菌疗效.
- 评估薄膜药物递送系统的细胞兼容性和物理性质.
主要方法:
- 用于薄膜制造的溶剂造方法.
- 用于材料表征的FTIR,XRD,SEM和EDX.
- 在PBS中进行的水接触角度,降解,胀和药物释放研究.
主要成果:
- 制造出均而光滑的薄膜,成功加载和分散塞法列辛.
- 石墨烯氧化物增强了热稳定性和水性;塞法莱克辛降低了热稳定性.
- 观察到pH值依赖的降解和胀,具有两阶段的塞法列辛释放配置文件.
结论:
- 开发的聚乙醇/氧化石墨烯薄膜适用于局部的塞法列辛输送.
- 这些片对阳性和阴性细菌表现出强大的抗菌活性.
- 该材料在相关度下表现出良好的细胞相容性,这表明了治疗潜力.
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