精神分裂症休息状态马功率:一个系统的审查和元分析
Yong Liu1,2, Pingping Xu3, Shaohua Hu1,2,4,5,6,7,8
1Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Frontiers in psychiatry
|February 4, 2026
概括
在精神分裂症患者中,静止状态马功率升高,但这种效应很小,并且有显著的变化. 诸如疾病持续时间和药物治疗等因素会影响这些马波段振荡发现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物医学工程 生物医学工程
背景情况:
- 马波段振荡对大脑功能至关重要,并与精神分裂症有关.
- 关于精神分裂症休息状态马活性的先前研究显示了不一致的结果.
研究的目的:
- 系统地审查和分析关于精神分裂症休息状态马活性的研究.
- 确定整体效应的大小,并确定导致异质性的因素.
主要方法:
- 对EEG和MEG研究进行系统审查和元分析.
- 包括20项研究 (998名患者,952名对照),使用纽卡斯尔-太华尺度评估质量.
- 使用随机效应模型计算聚合标准化平均差异 (Hedges' g).
主要成果:
- 在精神分裂症中显著的全脑马功率升高 (g=0.371).
- 在额叶和皮层观察到增加;在其他区域不一致.
- 疾病持续时间和药物状态预测了更高的马功率;眼睛开放条件减弱了效应.
结论:
- 精神分裂症的静止状态马功率差异是一个小的,异质的群体效应.
- 发现受到疾病持续时间,药物治疗和记录条件的影响.
- 需要对未经药物治疗的第一发病患者进行进一步的研究,以澄清机制.
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