中性粒细胞百分比与白蛋白比率作为一种新的血液学生物标志物,用于预测动脉源性勃起功能障碍
Yangyang Mei1, Guoyang Zhang2,3, Yu Liu2,3
1Department of Urology, Jiangyin People's Hospital, the Jiangyin Clinical College of Xuzhou Medical University, Jiangyin, Jiangsu, China.
Frontiers in endocrinology
|February 4, 2026
概括
中性粒细胞百分比与白蛋白比率 (NPAR) 与动脉性勃起功能障碍 (AED) 有关. NPAR显示AED的诊断能力比其他血液标志物更好,这表明它在评估血管风险方面具有潜力.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 血液学 血液学 血液学
- 心血管健康 心血管健康
背景情况:
- 中性粒细胞百分比与白蛋白比率 (NPAR) 是一种新的炎症和营养标志物.
- 它与动脉性勃起功能障碍 (AED) 的关联以前没有被探索.
研究的目的:
- 调查NPAR和AED之间的关系.
- 为了比较NPAR的诊断性能与AED的常规血液学标志物.
主要方法:
- 总共有265名男性 (115名患有AED,53名患有毒性ED,97名对照) 被纳入.
- 使用IIEF-5,NPTR和CDDU评估勃起功能.
- 测量了包括WBC,白蛋白和NPAR在内的实验室参数;进行了后勤回归和ROC分析.
主要成果:
- 与对照组和VED组相比,AED患者的WBC和NPAR水平显著更高.
- NPAR与AED (OR=1.258,P<0.001) 独立相关.
- 与WBC,NP,白蛋白,CRP和NLR相比,NPAR显示出AED (AUC=0.742) 的优异区分能力.
结论:
- 较高的NPAR水平与AED有显著的关联.
- 与其他血液学标记相比,NPAR对AED表现出优越的诊断性能.
- NPAR可能是一个有价值,具有成本效益的标志物,用于评估ED男性的血管风险.
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