高G3BP1表达与乳腺侵入性癌的预后不佳有关
Jingjing Li1, Zhiqiang Zong1, Jian Shen1
1Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
Oncology letters
|February 4, 2026
概括
拉斯-GTPase激活蛋白SH3域结合蛋白1 (G3BP1) 在侵袭性乳腺癌 (BRCA) 中被上调,表明预后不佳. 准G3BP1可能会改善BRCA诊断和免疫治疗.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 侵袭性乳腺癌 (BRCA) 是女性癌症死亡的主要原因.
- 目前的BRCA生物标志物具有有限的灵敏度和特异性.
- 在BRCA中Ras-GTPase激活蛋白SH3域结合蛋白1 (G3BP1) 的作用尚不清楚.
研究的目的:
- 调查G3BP1在BRCA中的临床相关性和机制性作用.
- 评估G3BP1作为BRCA的预后生物标志物.
- 探索G3BP1与信号通路和BRCA中的瘤免疫微环境的关联.
主要方法:
- 综合多主题数据分析 (TCGA,Timer,CPTAC) 和实验验证 (IHC).
- 使用卡普兰-梅尔生存分析和考克斯回归评估的预后值.
- 通过GSEA,CIBERSORT和TIMER分析信号通路和免疫细胞透.
主要成果:
- 在BRCA组织中,G3BP1在mRNA和蛋白质水平上显著上调.
- 高G3BP1表达与晚期淋巴结阶段和不良预后相关 (OS,DFS,DMFS,PPS).
- G3BP1与PI3K/AKT/mTOR信号传递,M2巨细胞透和减少CD8+T细胞透有关.
结论:
- G3BP1是BRCA的潜在独立预后生物标志物.
- 通过PI3K/AKT/mTOR通路激活和免疫微环境调节,G3BP1的上调促进了BRCA的进展.
- 研究结果支持针对G3BP1进行BRCA诊断和免疫治疗.
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