大麻使用障碍与术后并发症的关联:多中心倾向匹配分析
Jonathan Mokhtar1, John Y Ha2,3, Victor F A Almeida4
1College of Medicine (MBRU-CoM), Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
BMC plastic and reconstructive surgery
|February 4, 2026
概括
大麻使用障碍 (CUD) 与手术后疼痛和面膜切除术后的伤口并发症有关. 外科医生应对患者进行CUD查,以改善外科风险评估和患者的治疗结果.
科学领域:
- 整形外科 整形外科 整形外科
- 外科手术的结果
- 大麻研究 大麻研究
背景情况:
- 全球大麻使用的增加需要了解其手术影响.
- 大麻素会影响免疫,疼痛和血管路径,影响手术恢复.
- 大麻使用障碍 (CUD) 对下膜切除术结果的影响尚不清楚.
研究的目的:
- 为了确定CUD是否是一个独立的风险因素,在下膜切除术后出现并发症.
- 评估CUD和特定的术后不良事件之间的关联.
主要方法:
- 使用TriNetX研究网络 (2010-2025) 的回顾性队列研究.
- 倾向性得分匹配 (1:1) 患有CUD的患者与非使用者基于人口统计和并发症.
- 在90天内分析术后并发症,计算风险比率 (RR) 和95%置信区间 (CI).
主要成果:
- 在CUD队列中,术后疼痛 (RR 1.82) 和皮肤并发症 (RR 1.48) 的比率显著更高.
- 在败血症,血液瘤/血清瘤,静脉栓塞,肺栓塞或再入院率方面没有发现显著差异.
- 这项研究包括1596名匹配患者 (798名CUD,798名对照).
结论:
- 大麻使用障碍独立地与术后疼痛增加和术后伤口并发症相关.
- 对于CUD的手术前查,建议在诸如泛尼切除术之类的手术中进行.
- 限制包括依赖编码,缺乏剂量/路线数据以及潜在的尼古丁混.
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