长期COVID-19中小纤维神经病变的非侵入性电诊断测试
Anthony Khoo1,2,3, Kisani Manuel1,3,4, Tracy Ng2
1College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
BMJ neurology open
|February 4, 2026
概括
长期的COVID-19可以导致小纤维神经病变 (SFN),导致神经病变和自主症状. 多模式的非侵入性电诊断测试有助于评估受影响个体的这些症状.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 长期COVID-19呈现出各种神经病和自主症状.
- 这些症状可能表明小纤维神经病变 (SFN).
研究的目的:
- 评估多式无创电诊断技术的实用性.
- 为了评估COVID-19后疑似SFN的症状个体.
主要方法:
- 使用非侵入性SFN协议,包括同情皮肤反应,皮肤静止期,定量热值和电化学皮肤导电.
- 进行了常规的神经生理检测和全面的临床,心理测量和功能评估.
- 包括小纤维神经病查表 (SFNSL) 调查问卷,6分钟步行测试,NASA瘦身测试,COMPASS-31,ED-5D-5L,MFIS和PHQ-9.
主要成果:
- 在9名 (33%) 个体中,有3人表现出神经生理学上的SFN证据.
- 参与者的平均年龄为47.8岁,COVID-19感染后的平均时间为23.0个月.
- 所有人都报告了严重的残疾和生活质量下降.
结论:
- 长期的COVID-19与功能障碍和生活质量下降有关.
- 在出现神经病和自主症状的患者中,应考虑SFN.
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