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耐受性和加速器:开源手腕加速度测量与前列腺癌的安卓废除老年男性的症状负担有关
Nabiel Mir1, Konstantinos Ameranis2, Yan Che3
1Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Digital biomarkers
|February 4, 2026
概括
手腕加速度计可以追踪老年男性的症状负担,这些老年男性正在接受前列腺癌的雄激素剥夺疗法 (ADT). 焦虑和节奏平衡等光谱特征显示出远程症状监测的前景.
科学领域:
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
背景情况:
- 接受雄激素剥夺疗法 (ADT) 的前列腺癌老年男性经历了显著的症状负担.
- 在临床检查期间,症状往往被低估,因此需要远程监测解决方案.
- 以前的研究强调了频域特征对老年障碍的预测能力.
研究的目的:
- 为了确定加速度特征来跟踪每周的症状负担在ADT的老年男性.
- 描述这些特征的时间尺度,重点是光谱测量.
- 探索开源手腕加速度计对监测前列腺癌患者的实用性.
主要方法:
- 一项涉及10名患有转移性前列腺癌的男性 (≥65岁) 的试点研究的回顾性分析.
- 每周的症状负担和自我评估的健康数据收集了超过100天.
- 48小时,10赫兹的手腕加速度计数据被处理成60秒计数-每分钟 (CPM) 和向量-幅度变化,从中提取了98个特征.
主要成果:
- 两个可解释的CPM光谱特征,不安 (CPM_top_15_freq3) 和全球节律平衡 (CPM_median_freq),与每周的症状负担一致相关.
- 随着症状负担的增加,不安增加了 (ρ = +0.95; p = 0.012),而节律平衡的转移较低 (ρ = -0.88; p = 0.049).
- 这些特征在惩罚性回归和随机森林分析中都很强大.
结论:
- 来自手腕加速度计的可解释的光谱特征显示了在ADT上跟踪前列腺癌老年男性的症状负担的潜力.
- 研究结果表明,远程监测症状是可行的,但需要进行前性验证.
- 这种方法可能有助于捕捉通常在标准临床护理中错过的症状波动.
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