益生菌和益生菌机制在IBD相关的结直肠癌发生:最近的进展
Xueru Fan1,2, Xiaoge Wang1, Yang Chao1,2
1Department of Gastroenterology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Frontiers in nutrition
|February 4, 2026
概括
炎症性肠病 (IBD) 增加了结直肠癌 (CRC) 的风险. 益生菌和益生菌在调节肠道微生物群和炎症方面表现有希望,以预防IBD相关的CRC.
科学领域:
- 胃肠道学和瘤学
- 微生物组研究 微生物组研究
背景情况:
- 炎症性肠病 (IBD) 是一种慢性炎症状况,与结直肠癌 (CRC) 风险增加有关.
- 肠道微生物失调和持续的肠道炎症是IBD相关结直肠癌发生的关键驱动因素.
研究的目的:
- 审查IBD-CRC中炎症,微生物群和免疫之间的相互作用.
- 探索益生菌和益生菌在IBD-CRC预防和治疗中的作用.
主要方法:
- 在IBD-CRC中整合炎症,微生物群和免疫机制的文献综述.
- 专注于益生菌和益生菌对微生物生态,屏障完整性,炎症和抗瘤免疫的影响.
- 关于益生菌和益生菌前益生菌有效性的临床前和临床证据的讨论.
主要成果:
- 益生菌和益生菌可以重塑肠道微生物群,增强表皮屏障功能,并抑制炎症信号传递.
- 这些干预措施可能会激活抗瘤免疫力,可能会延迟或预防IBD-CRC.
- 临床前和临床研究的证据支持它们的治疗潜力.
结论:
- 益生菌和益生菌有望通过向微生物失生症和炎症来管理IBD-CRC.
- 未来的研究应该专注于针对微生物群的向治疗和癌症预防的定制共生策略.
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