由复合和活衰减疹疫苗引起的Fc介导的免疫效应器功能
Zhuangzhuang Huang1, Pengfei Jin2, Hongxing Pan1,2
1School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, China.
在RZV疫苗诱导更强的Fc介导免疫反应对VZV-gE比ZVL. 在接种疫苗后,年轻人表现出比老年人更好的Fc效应器功能.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 通过Fc介导的免疫反应来保护疹 (shingles) 的保护尚未完全理解.
- 评估Fc介导的抗体对VZV糖蛋白E (gE) 诱导的Fc介导免疫反应,由两种授权的麻疹病毒 (VZV) 疫苗诱导.
研究的目的:
- 为了比较由ZVL和RZV疫苗诱导的Fc介导免疫反应.
- 评估抗体依赖的细胞毒性 (ADCC),细胞化 (ADCP) 和中性细胞化 (ADNP) 对VZV-gE.
- 分析Fc介导功能与IgG水平之间的相关性.
主要方法:
- 48名健康参与者 (≥50岁) 的两个队列接受了ZVL或RZV.
- 对VZV-gE的ADCC,ADCP和ADNP进行了血清样本分析.
- 研究了Fc介导功能与IgG水平之间的相关性.
主要成果:
- 两种ZVL和RZV疫苗都诱导了Fc效应器功能对VZV的反应.
- 与ZVL接收者相比,RZV接收者表现出明显更高的ADCC反应 (8.44倍对1.93倍).
- 较年轻的接种者在两个疫苗组中表现出较高的ADCC,ADCP和ADNP反应,而不是老年接种者.
结论:
- 与ZVL相比,RZV诱导了VZV-gE抗体的优越Fc效应函数.
- 与年轻人相比,老年人在接种疫苗后表现出较弱的Fc介导反应.
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