在非随机研究的系统审查中应用ROBINS-I指南:一项描述性研究
Zipporah Iheozor-Ejiofor1, Jelena Savović1, Russell J Bowater1
1Population Health Sciences, Bristol Medical School, https://ror.org/0524sp257University of Bristol, Bristol, UK.
Research synthesis methods
|February 4, 2026
概括
大多数对干预的非随机研究 (NRSI) 的系统性审查并不完全应用ROBINS-I偏差风险指南. 这影响了用于决策的证据的可靠性.
科学领域:
- 医学研究方法论医学研究方法论.
- 基于证据的医学是基于证据的医学.
- 系统性审查质量评估的质量评估.
背景情况:
- 干预的非随机研究中的偏差风险 (ROBINS-I) 工具对于评估系统审查中的证据质量至关重要.
- 准确报告ROBINS-I评估对于决策者和临床医生的知情决策至关重要.
- 系统审查作者遵守ROBINS-I指南对于保持方法论严谨性至关重要.
研究的目的:
- 评估系统审查作者目前在多大程度上遵守ROBINS-I工具的指导.
- 在最近的系统性审查中,确定与ROBINS-I应用和报告标准的常见偏差.
主要方法:
- 在2023年1月进行了系统的引用搜索,选了前六个月的记录.
- 包括使用ROBINS-I工具对干预措施的非随机研究中偏差风险评估的系统审查.
- 对10个标准进行了评估,以总结与ROBINS-I指导和报告实践的偏差.
主要成果:
- 在包含的492个审查中,只有一个完全符合ROBINS-I指导期望.
- 一小部分评论偏离了标准领域 (3%) 或判断 (13%).
- 只有12%的审查报告了ROBINS-I结果在结果层面,而在研究层面报告的比例为67%.
结论:
- 大多数包含对干预措施的非随机研究的系统性审查并未完全实施ROBINS-I指南.
- 不一致的ROBINS-I应用和报告引发了对偏见风险评估的有效性和随后使用证据的担忧.
- 需要改善培训和遵守ROBINS-I指南,以提高系统审查结果的可靠性.
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