使用PSO-BPNN和NSGA-III优化周围静脉血:平衡送效率和血液兼容性
Jun Zhang1, RuiGui Huang1, HongTao Zhang2
1School of Mechanical and Power Engineering, Zhengzhou University, Zhengzhou, China.
Computer methods in biomechanics and biomedical engineering
|February 4, 2026
概括
优化围静脉用于可穿戴透析,这项研究引入了使用代用模型的成本效益高的工作流程. 新的设计提高了流速和血液相容性,减少了剪切应力和血液溶解.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 计算建模 计算建模
背景情况:
- 环静脉对于可穿戴透析设备至关重要.
- 由于复杂的流体结构相互作用 (FSI),优化性能 (流量,血液兼容性) 是一个挑战.
- 传统的3D双向FSI模拟在计算上是昂贵的.
研究的目的:
- 开发一个高效的代理辅助工作流程,以优化用于可穿戴透析的环静脉.
- 为了提高流速和血液相容性,同时最大限度地减少剪切应力和血液溶解.
- 为了降低与传统的FSI分析相关的计算成本.
主要方法:
- 结合3D双向流体结构相互作用 (FSI) 与粒子群优化逆向传播神经网络 (PSO-BPNN) 替代模型.
- 使用非主导排序基因算法III (NSGA-III) 进行多目标优化.
- 使用权重的TOPSIS进行决策,以选择最佳设计.
- 用60个样本来训练代孕模型,以确定关键性能指标:平均流量 (f_ave),时间平均剪切应力 (τ_ave) 和剪切应力脉冲 (τ_p).
主要成果:
- 替代模型实现了高精度,f_ave的R2值为0.97,t_ave的0.91,t_p的0.94.
- 优化的设计实现了平均流量为208.79毫升/分钟.
- 与基线相比,时间平均剪切应力 (τ_ave) 显著减少6.30%,剪切应力脉冲 (τ_p) 显著减少40.76%.
- 降低了预测的血液溶解指数6.71%.
结论:
- 代理辅助工作流提供了一种高效且具有成本效益的方法,用于优化用于可穿戴透析的环静脉.
- 经过优化设计,在流量和血液兼容性方面表现得更好.
- 这种方法为推进可穿戴透析技术提供了一个可行的解决方案,通过减少血液损伤的风险来推进可穿戴透析技术.
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