Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

9.6K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
9.6K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.3K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.3K
What is the Immune System?01:38

What is the Immune System?

129.7K
Overview
129.7K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

3.9K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.9K
Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Epigenetic Regulation01:46

Epigenetic Regulation

33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial.

Nature cancer·2026
Same author

Intrathecal nivolumab in metastatic solid tumors with leptomeningeal disease: dose escalation part of the multicenter IT-PD1/NOA-26 phase 1 trial.

Nature cancer·2026
Same author

Regulation of immune checkpoint molecules in cancer immune evasion and therapy.

Nature reviews. Cancer·2026
Same author

End-of-life challenges in neuro-oncological patient care: A survey from the Junge Neuroonkologische Arbeitsgemeinschaft.

Neuro-oncology practice·2026
Same author

Type I interferon drives T cell responses to amyloid beta in the central nervous system.

Nature communications·2026
Same author

Inhibition of high CXCR4 with Motixafortide and absence of single-cell MRD predict outcome after AML consolidation.

Blood·2026

相关实验视频

Updated: Feb 5, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

10.9K

在癌症中产生的免疫检查点的组织特异空间调节.

Ana Stojanovic1, Sebastiano Giorgetta1, David Vonhören2

  • 1Heidelberg University Mannheim Germany.

Cancer discovery
|February 4, 2026
PubMed
概括

自然杀手细胞 (NK) 和先天性淋巴细胞 (ILC) 对组织健康和免疫非常重要. 针对癌症中的监管检查点可能会导致固体瘤的新疗法.

更多相关视频

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

12.1K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.8K

相关实验视频

Last Updated: Feb 5, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

10.9K
Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

12.1K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 细胞生物学 细胞生物学

背景情况:

  • 自然杀手 (NK) 细胞和先天性淋巴细胞 (ILC) 是组织平衡和免疫反应的关键调节者.
  • 这些细胞作为细胞应激和组织功能障碍的早期传感器,其功能由调节电路和局部环境控制.
  • 在癌症中,组织变化引发免疫细胞的招募,再分配和功能适应.

研究的目的:

  • 讨论组织特异性线索如何调节癌症中的NK/ILC功能.
  • 探索当地调节电路如何塑造NK/ILC细胞状态和效应器程序.
  • 为了解决针对癌症治疗的先天检查点的潜力.

主要方法:

  • 对癌症NK/ILC调节现有文献的综述.
  • 对影响NK/ILC功能的组织特异性线索和局部调节电路的分析.
  • 讨论针对先天检查点的潜在治疗策略.

主要成果:

  • 组织特异性线索在瘤微环境中显著影响NK/ILC功能.
  • 当地调节回路决定NK/ILC细胞状态和癌症中的效应器功能.
  • 针对先天的检查点为新型癌症疗法提供了一个有希望的途径.

结论:

  • 了解NK/ILCs的特定组织调节对于癌症免疫学至关重要.
  • 针对先天的检查点提供了增强现有和开发新癌症治疗的潜力.
  • 对NK/ILC调节的进一步研究可以为固体恶性瘤的创新治疗策略提供信息.