对神经血管与年龄相关的黄斑退化进行放射治疗:系统性审查和元分析
Yiou Lei1,2,3, Jiaqi Yang1,2,3, Ying Li1,2,3
1Xiangya School of Medicine, Central South University, Changsha, PR China.
Current eye research
|February 4, 2026
概括
与抗VEGF药物相结合的放射治疗用于新血管与年龄相关的黄斑变性 (nAMD) 显示出混合的结果. 脑膜支臂疗法增加了视力损失的风险,而立体辐射疗法减少了注射频率,但没有改善视力敏度.
科学领域:
- 眼科医生 眼科 眼科
- 辐射瘤学 辐射瘤学
- 医学科学 医学科学 医学科学
背景情况:
- 抗血管内皮生长因子 (抗VEGF) 药物是新血管与年龄相关的黄斑变性 (nAMD) 的标准.
- 抗VEGF单一治疗存在局限性,需要探索组合治疗.
- 放射治疗为nAMD提供了潜在的辅助疗法.
研究的目的:
- 评估放射治疗与抗VEGF治疗相结合的疗效和安全性,与针对nAMD的抗VEGF单一治疗相比.
- 为了比较两种放射治疗方式:表膜支臂疗法 (EBM) 和立体辐射疗法 (SRT).
主要方法:
- 四项研究 (七篇文章) 的系统综述和元分析.
- 搜索了主要的数据库 (PubMed,Embase,Cochrane等等) 截至 2025 年 2 月 25 日.
- 主要结果:参与者在12个月和24个月失去>15个ETDRS信件的比例.
主要成果:
- 与抗VEGF单独治疗相比,在12个月和24个月内与抗VEGF药物结合的表皮支臂治疗 (EBM) 会增加视力损失的风险.
- 与抗VEGF结合的立体辐射疗法 (SRT) 显示,24个月后视力丧失的风险更高,但拉尼比祖马布注射量减少了2.10.
- 在SRT组合治疗中,没有观察到最佳校正视敏度 (BCVA) 的显著改善.
结论:
- 结合抗VEGF的EBM可能会使结果恶化,并增加nAMD的不良事件.
- 与抗VEGF药物结合的SRT可以通过减少抗VEGF注射频率来降低治疗负担.
- 需要进一步的研究来优化放射治疗在nAMD管理中的使用.
关键词:
在此之前,AMD是AMD.这是一种反-VEGF的药物.脊髓上支臂疗法 (Epimacular Brachytherapy) 是一种治疗方式.辐射疗法 辐射疗法立体电磁辐射疗法 立体电磁辐射疗法更多相关视频
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