围绕性超声波脏脱,针对主要脏动脉和分支:首次对人类进行研究
Zhifeng Yao1, Meng Ji1, Yizhe Wu1
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University; NHC Key Laboratory of Ischemic Heart Diseases; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences; National Clinical Research Center for Interventional Medicine, Shanghai, China.
JACC. Asia
|February 4, 2026
概括
超声波缺血 (uRDN) 是一种安全且可行的治疗方法,用于控制不良的高血压. 这种新的方法在早期人类试验中显示出显著的血压降低.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 抗性高血压仍然是一个重大的临床挑战,需要新的治疗策略.
- 脏剥皮的目的是减少交感神经系统的活动,从而导致高血压.
- 超声波损伤 (uRDN) 提供了一种潜在的非侵入性方法来调节神经活动.
研究的目的:
- 为了评估一个环形超声波脏缩 (uRDN) 系统的可行性和安全性.
- 评估RRDN在降低无控高血压患者的血压效果.
- 在临床前的模型中,研究RRDN对脏诺亚上腺素水平的影响.
主要方法:
- 在猪模型 (n=6) 和首次对人类的可行性研究 (n=5) 中测试了一个环形RRDN系统.
- 关键的终点包括设备相关的不良事件和24小时门诊血压的变化.
- 临床前评估包括在手术后测量脏的诺亚上腺素水平.
主要成果:
- 临床前研究显示了有利的安全性概况和超过97%的性诺亚上腺素的减少.
- 所有的人体手术在技术上都是成功的,没有设备相关的不良事件.
- 在6个月后,观察到24小时门诊静脉压和静脉压显著降低 (16/8 mm Hg).
结论:
- 周围RRDN是一种可行且安全的方法来治疗不受控制的高血压.
- 这些初步数据支持RRDN作为高血压患者治疗选择的潜力.
- 需要在更大的试验中进行进一步的研究,以确认长期的疗效和安全性.
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