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Updated: May 27, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

杜洛特格拉维尔单疗失败的HIV-1整合酶自然多态基因K156N和3'PPT突变之间的合作

Jolieke A T van Osch1, Jolanda J C Voermans1, Haajar Ouzerne1

  • 1Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.

The Journal of antimicrobial chemotherapy
|February 4, 2026
PubMed
概括

一种天然的HIV-1整合酶多态性 (K156N) 可以使个体易受3'多素通道 (3'PPT) 突变的影响,这些突变与用杜洛特格拉维尔治疗失败有关. 这项研究阐明了HIV-1耐药性的罕见突变途径.

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