在使用国家索赔数据库的血友病A患者中,艾米齐祖马布在现实世界中的坚持和持久性
Janet S Lee1, Robert Schuldt1, Zhiyu Xia1
1Genentech, Inc., South San Francisco, CA.
Journal of managed care & specialty pharmacy
|February 4, 2026
概括
在美国,在患有血友病A (PwHA) 的人群中观察到艾米齐祖马布的高度坚持和持续性. 这些真实世界的数据显示了艾米齐祖马布治疗在血友病A管理中的有希望的结果.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 现实世界的证据.
背景情况:
- 在患有血友病A (PwHA) 的人群中,不坚持因子VIII (FVIII) 替代疗法是常见的,影响健康结果.
- 埃米齐祖马布是一种新型双特异性抗体,为PwHA提供了一种新的预防方案.
- 关于埃米齐祖马布的坚持和持续性的真实世界数据对于治疗决策至关重要.
研究的目的:
- 为了评估现实世界中的依从性和持续性,在美国PwHA的EMICIZUMAB.
- 评估FVIII在坚持使用埃米齐祖马布的用户中的使用情况.
主要方法:
- 使用美国健康计划索赔数据进行回顾性观察队列研究.
- 包括PwHA连续保险覆盖至少6个月的指数前和12个月的指数后.
- 坚持度以覆盖日数的比例来衡量 (PDC ≥80%);持久性定义为没有≥60天的治疗间隔.
主要成果:
- 包括280个PwHA;98%是男性,平均年龄26岁.
- 总体上,坚持率为76%,持久率为85%.
- 在加入PwHA (n=213) 的人中,57%没有FVIII索引后的索赔.
结论:
- 在真实世界的美国环境中,观察到埃米齐祖马布的高坚持和持久率.
- 在第一年开始使用埃米齐祖马布时,表现出良好的坚持和低停药率.
- 这些发现支持埃米齐祖马布作为PwHA的有效治疗选择.
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