牛骨原蛋白/阿斯特拉类多糖化合物的组合对骨矿物质密度及其潜在机制的改善作用
Xiaozhou Wang1, Shikun Suo1, Yanli Wang1
1College of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China. dangyali@nbu.edu.cn.
Food & function
|February 4, 2026
概括
结合牛骨原蛋白 (BBCP) 和阿斯特拉加勒斯多糖 (APS) 显著提高骨矿物质密度 (BMD) 超过单个成分. 这种由p38 MAPK途径介导的协同效应,为骨质疏松症管理提供了一种新的方法.
科学领域:
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 骨质疏松症的特点是骨矿物质密度 (BMD) 的降低.
- 单独使用多和多糖来改善骨质疏松是常见的,但联合使用的协同效应和机制尚不清楚.
- 食品药物同质性和多目标网络调节理论指导着组合补充剂的研究.
研究的目的:
- 调查牛骨原蛋白 (BBCP) 和阿斯特拉加卢斯多糖 (APS) 组合对骨矿物质密度 (BMD) 的协同效应.
- 阐明BBCP/APS组合的协同效应的潜在机制.
- 探索BBCP/APS组合作为骨质疏松症管理的功能性食物的潜力.
主要方法:
- 使用了体外骨质细胞模型和体内卵巢切除术 (OVX) 的老鼠模型.
- 使用网络药理学分析来确定核心目标和途径.
- 评估了骨质标记物,股骨骨质量,以及椎骨微架构.
主要成果:
- 与单个成分相比,BBCP/APS组合显著增强了骨质母细胞的增殖,并提高了骨质生殖标志物的调节.
- 在体内,BBCP/APS治疗增加了OVX大鼠的股骨骨质量和改善了椎骨微架构.
- 网络药理学确定ADRA1A和ADRA2A是核心点,p38 MAPK通路被证实是主要的信号通路.
结论:
- BBCP/APS组合在增强骨硬化方面表现出协同效应,超过单个成分的有效性.
- 协同机制涉及p38 MAPK通路的激活.
- 这种组合有望促进功能性食物的开发,以对抗骨质疏松症.
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