相关实验视频
Updated: Feb 6, 2026

07:16
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
35.1K
针对性组织的热预条件增强了脉冲场除病变
Daniel Campos-Villarreal1, Maxwell Coll1, Logan McClennen1
1Cardiac Arrhythmia Service, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
概括
热预调显著影响脉冲场切除 (PFA) 损伤的形成. 在PFA之前加热组织会增加病变大小,而冷却会减少病变大小,这表明温度是PFA有效性的关键因素.
科学领域:
- 心血管切除技术的使用.
- 电穿孔生物物理学 生物物理学
- 医疗器械研究 医疗器械研究
背景情况:
- 脉冲场切除 (PFA) 使用不可逆的电穿孔 (IRE) 进行心脏切除,与热方法不同.
- 温度和导电性等组织特性会影响PFA病变的形成,但需要进一步描述.
研究的目的:
- 为了研究热预调对PFA损伤特征的影响.
- 建立一个受控的体外模型来评估与组织温度相关的PFA.
主要方法:
- 马组织板在各种温度 (冷,控制,加热) 进行了预调.
- 使用标准化的电压和脉冲参数的3.5毫米电极导管应用PFA.
- 用2,3,5-triphenyltetrazolium化物 (TTC) 染色后测量了损伤尺寸.
主要成果:
- 预热组织至40°C,与对照组 (25.3mm) 相比,损伤直径 (34.1-35.0mm) 显著增加.
- 加热的组织也显示病变深度增加 (12.23毫米对比10.7毫米).
- 将组织冷却到10°C以下显著减少了病变直径 (23.1mm) 和深度 (9.3mm).
结论:
- 在体外,热预条件显著改变PFA病变的大小和深度.
- 提高组织温度可能会通过降低电穿孔值来提高PFA的有效性.
- 组织温度是一个可改变的因素,影响脉冲场切除的有效性.
相关概念视频
Pulse
2.2K
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
The pulse serves as a clinical...
2.2K
Pulse
4.1K
The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
4.1K
Thermal expansion and Thermal stress: Problem Solving
2.2K
San Francisco's Golden Gate Bridge is exposed to temperatures ranging from -15 °C to 40 °C. At its coldest, the main span of the bridge is 1275 m long. Assuming that the bridge is made entirely of steel, what is the change in its length between these temperatures?
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
2.2K
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences
1.8K
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
1.8K
Pulse Oximetry
1.4K
Pulse oximetry, or SpO2, is a non-invasive method for continuously monitoring arterial oxygen saturation (SaO2). This procedure involves attaching a probe or sensor to the patient's fingertip, forehead, earlobe, or nose bridge. The sensor works by detecting changes in oxygen saturation levels through light signals generated by the oximeter and reflected by the pulsing blood under the probe.
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
1.4K
Regulation of Pulse
2.3K
Pulse regulation involves physiological mechanisms that ensure adequate blood flow throughout the body. The heartbeat, regulated by the autonomic nervous system, is influenced by hormonal balance, physical activity, and emotional state.
2.3K

