乳酸盐和酸化:骨关节炎的新兴代谢调节剂
Yan-Hong Lin1,2, Yi-Hua Chen1,3, Tai-Ran Zhu1,2
1The Key Laboratory of Pathobiology of the Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Current medical science
|February 4, 2026
概括
乳酸是细胞代谢的产物,在骨关节炎 (OA) 中发挥着双重作用,通过加剧软骨损伤,同时帮助炎症解决. 向乳酸通路可能提供新的OA疗法.
科学领域:
- 生物化学 生物化学
- 病理学 病理学 病理学
- 代谢医学是一种代谢医学.
背景情况:
- 骨关节炎 (OA) 是一种广泛的退行性和炎症性关节疾病,具有巨大的社会成本.
- 代谢功能障碍,特别是糖溶性重编程,越来越多地与OA的发病有关.
- 乳酸在关节微环境中的积累是OA的一个关键特征.
研究的目的:
- 审查当前关于乳酸在骨关节炎中的作用的证据.
- 阐明甲状腺炎中软质细胞和巨细胞中糖溶性重编程的机制.
- 探索乳酸在OA病变发生中的双重功能及其治疗潜力.
主要方法:
- 文献综述综合了目前关于OA乳酸代谢的证据.
- 在受OA影响的细胞中,基底的糖溶性重编程机制的概述.
- 对乳酸对软骨退化和炎症影响的分析.
主要成果:
- 糖溶性重编程导致OA关节中显著的乳酸积累.
- 乳酸具有双重作用:加剧软骨退化和促进炎症的解决.
- 关键的媒介包括细胞外酸化,HCAR1和乳酸化.
结论:
- 乳酸通过复杂的机制显著影响OA的发病.
- 乳酸的双重作用为OA提供了一个治疗目标.
- 调节乳酸流提供了OA预防和管理的潜力.
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