治疗耐药抑郁症的性饮食:一项随机临床试验
Min Gao1,2, Megan Kirk1,2, Heather Knight1
1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England.
JAMA psychiatry
|February 4, 2026
概括
在治疗耐药性抑郁症 (TRD) 的成年人中,基因饮食 (KD) 在六周后显示出与控制饮食相比的抗抑郁益处. 然而,由于适度的效果大小和缺乏二次结果差异,临床意义仍然不确定.
科学领域:
- 营养精神病学 营养精神病学
- 代谢干预 代谢干预
- 心理健康研究 心理健康研究
背景情况:
- 临床前研究和病例报告表明,性饮食 (KDs) 可能有利于抑郁症.
- 随机临床试验 (RCT) 对抑郁症中KD疗效的强有力的证据有限.
- 耐治疗抑郁症 (TRD) 仍然是一个重大的临床挑战,治疗需求尚未得到满足.
研究的目的:
- 为了评估KD与对照饮食相比,KD在被诊断为TRD的成年人中的有效性.
- 为了确定KD是否可以在TRD人群中显著改善抑郁症状.
- 评估KD对各种与心理健康和功能相关的次要结果的影响.
主要方法:
- 进行了一项随机对照试验 (RCT),涉及88名患有TRD的成年人 (18-65岁).
- 参与者被随机分配1:1分为6周的性饮食 (KD) 或控制 (植物) 饮食,两者都提供饮食支持.
- 主要结局指标是从基线到第6周的9项患者健康问卷 (PHQ-9) 得分的变化.
主要成果:
- 在KD和对照组中,PHQ-9分数显著降低.
- 与对照组相比,KD组在6周内在PHQ-9得分上表现出了统计学上显著的,尽管是适度的,但更大的降低 (平均差异-2.18,P=.05).
- 在6周或12周的二次结果中,没有观察到两组之间有显著差异,也没有报告任何严重不良事件.
结论:
- 在治疗耐药性抑郁症 (TRD) 的成年人中,基因饮食 (KD) 与控制饮食相比,在6周内表现出抗抑郁作用.
- 观察到的益处的临床相关性是不确定的,原因是适度的效果大小和二次结果中缺乏重要的发现.
- 需要进一步的研究来澄清KDs在治疗抑郁症的长期疗效和临床效用.
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