在美国退伍军人中识别状黑色素瘤的危险因素
Jonathan C Hwang1,2,3, Linden B Huhmann4, Kelly Cho4,5,6
1University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
JAMA dermatology
|February 4, 2026
概括
暴露于色剂 (AOE) 与美国退伍军人的状黑色素瘤 (AM) 风险增加有关. 吸烟与较低的AM几率有关,而之前的皮肤疾病,如角质细胞癌 (KC) 和行为性角质瘤 (AK) 显示出混合的关联.
科学领域:
- 皮肤病学和瘤学
- 退伍军人健康研究研究
- 环境流行病学环境流行病学
背景情况:
- 状黑色素瘤 (AM) 是一个独特的亚型,发生在手掌,脚和指甲单位,与紫外线辐射暴露较少相关.
- 关于AM风险因素的研究有限,特别是在美国退伍军人人口中.
- 了解这些因素对于有针对性的预防和早期检测战略至关重要.
研究的目的:
- 在一组美国退伍军人中识别和分析与状黑色素瘤 (AM) 相关的风险因素.
- 为了比较AM的风险因素与非性皮肤黑色素瘤 (CM) 和没有黑色素瘤的个体.
主要方法:
- 从2000年到2024年,在退伍军人事务 (VA) 医疗保健系统中进行了一项嵌套病例控制研究.
- 使用VA癌症注册表和病理学报告的自然语言处理识别了Acral黑色素瘤病例.
- 根据诊断年份和门诊访问频率,病例与对照组 (没有黑色素瘤和非性CM) 相匹配.
主要成果:
- 与非黑色素瘤对照组和CM对照组相比,暴露于色剂 (AOE) 与AM的几率增加有显著的关联.
- 目前的吸烟表明与发展AM的几率较低有显著的关联.
- 之前的角质细胞癌 (KC) 和行为性角质瘤 (AK) 与较高的AM几率相比没有黑色素瘤,但与CM相比较低的几率有关;之前的瘤与较高的AM几率相比没有黑色素瘤有关.
结论:
- 该研究确定了与美国退伍军人中AM相关的关键因素,包括AOE和吸烟状态.
- 这些发现支持将AM作为与皮肤黑色素瘤 (CM) 截然不同的实体进行调查.
- 结果可能会为未来关于AOE和AM协会的研究提供信息,特别是在老兵人群中.
相关概念视频
Factors Affecting the Risk of Infection
13.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.6K
Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Transcription Factors
82.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K
Factors Affecting Solubility
37.2K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K
Transcription Elongation Factors
14.0K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.0K
Factors Affecting Drug Distribution: Miscellaneous Factors
994
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
994


