银(I) 复合物与N-methylphenothiazine作为具有多目标作用模式的潜在抗菌剂
Tina P Andrejević1, Jovica Branković1, Tatjana Ilic-Tomic2
1University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia. violeta.markovic@pmf.kg.ac.rs.
Dalton transactions (Cambridge, England : 2003)
|February 4, 2026
概括
三种新的含有N-Methylphenothiazine (N-Mephtz) 配方体的银 (I) 复合物显示出有前途的抗菌活性. 复合物1对细菌和真菌具有显著的疗效,具有潜在的抗癌作用和DNA结合能力.
科学领域:
- 协调化学 协调化学
- 药用无机化学 药用无机化学
- 生物物理化学 生物物理化学
背景情况:
- 银 ((I) 复合体因其多样化的生物活动而被探索.
- 提亚衍生物作为协调化学中的多功能连接体.
- 作为一种新型金属复合物的联体,N-Methylphenothiazine (N-Mephtz) 正在被研究.
研究的目的:
- 用N-Mephtz.合成和表征新的银(I) 复合物.
- 评估这些复合物的抗微生物,细胞毒性和生物分子相互作用特性.
- 使用计算方法研究结构和电子特性.
主要方法:
- 银I) 复合物的合成:[AgN-Mephtz) ]X (X=CF3SO3-,SbF6-,PF6-). 银I) 复合物的合成:[AgN-Mephtz) ]X (X=CF3SO3-,SbF6-,PF6-). 银I) 复合物的合成:[AgN-Mephtz) ]X (X=CF3SO3-,SbF6-,PF6-).
- 单晶X射线衍射和光谱方法 (IR,UV-Vis) 的结构特征.
- 抗菌试验,细胞毒性评估 (A549,HCT116细胞系),DNA/BSA结合研究,DFT/TD-DFT计算和分子对接.
主要成果:
- 四个N-Mephtz配合体通过硫协调到银(I),形成阴阳性[Ag(N-Mephtz) 4+物种.
- 综合体1对所有测试菌株 (MIC 8-30μg mL-1) 呈现出显著的抗菌活性.
- 复合体对癌症细胞系表现出细胞毒性,并通过小沟与ct-DNA显著结合.
结论:
- 合成的银 (I) 复合物具有显著的抗微生物和潜在的抗增殖活性.
- 复合物1是作为抗菌剂进一步开发的有希望的候选物.
- 需要进一步的结构优化来增强选择性和减少哺乳动物细胞细胞毒性.
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