梅洛伊多基尼线虫重编程树枝球代谢以抑制敌对的微生物群,并使细菌病原体的共同感染成为可能
1The Sanya Institute of the Nanjing Agricultural University, Key Lab of Organic-Based Fertilizers of China, Jiangsu Provincial Key Lab for Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing Jiangsu 210095, China; JF Blumenbach Institute of Zoology and Anthropology, University of Göttingen, 37073 Göttingen, Germany.
根结线虫破坏植物免疫和土壤微生物群,使细菌病原体的共感染成为可能. 这项研究揭示了线虫入侵如何改变植物新陈代谢,促进疾病宽容性条件,并突出了基于微生物组的作物保护目标.
科学领域:
- 植物病理学 植物病理学
- 微生物组研究 微生物组研究
- 农业科学 农业科学
背景情况:
- 根结线虫通过削弱植物防御和增加对细菌病原体的敏感性,显著降低了作物产量.
- 线虫促进这些共感染的确切机制尚不清楚.
研究的目的:
- 调查线虫病原体共感染的全球流行情况.
- 通过使用多原子分析,阐明菌促进的共感染背后的分子和微生物机制.
主要方法:
- 线虫病原体共感染的全球流行率评估.
- 在温室和体外实验中进行多原子分析 (基因组学,代谢学).
- 合成微生物社区移植实验.
主要成果:
- 线虫的入侵触发了植物的防御基因,但也破坏了树根球的恒常性,导致了微生物群的失生症,取代了宿主抵抗.
- 梅洛伊多基因的入侵会导致新陈代谢的转变,耗尽托马提丁,并积累像银河糖这样的碳水化合物.
- 这些代谢变化抑制了有益的Streptomyces,同时丰富了支持病原体Ralstonia的Acidovorax,将细菌组转换为病原体宽容状态.
结论:
- 线虫和细菌病原体合作颠覆植物微生物的代谢信号,损害了根球的免疫力.
- 了解这些相互作用揭示了开发基于微生物组的作物疾病控制策略的潜在目标.
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