在两个愈合时间点上对上鼻腔底部增大治疗骨移植愈合的组织学评估:随机临床试验
Ricardo Pasquini Filho1, Leandro Eduardo Klüppel1, Rubens Moreno de Freitas1
1Department of Implant Dentistry at the Latin American Dental Research and Teaching Institute College(ILAPEO). CuritibaPR/ Brazil.
Brazilian dental journal
|February 4, 2026
概括
在用牛骨移植进行大鼻腔升高手术后8个月的愈合期,与4个月的时间相比,显著提高了新的骨形成和成熟. 这种延长的愈合优化了用于牙科植入物的移植骨质量.
科学领域:
- 口腔和牙面部外科手术
- 恢复性牙科 恢复性牙科
- 生物材料科学 生物材料科学
背景情况:
- 腔鼻床的升高对于在缩后部的牙植入物放置至关重要.
- 烧结的牛骨移植是通常用于骨再生的生物材料.
- 优化愈合期对于可预测的骨增强结果至关重要.
研究的目的:
- 为了比较4个月和8个月的愈合期对使用烧结牛骨移植进行大鼻膜增大后骨形成的组织学和组织形态学影响.
- 评估不同愈合时间对骨替代物再吸收和软组织整合的影响.
主要方法:
- 分口设计,涉及14名参与者,用烧结的牛骨移植进行上鼻腔底部升高.
- 随机分为4个月 (试验组) 和8个月 (对照组) 的愈合期.
- 组织学和组织形态学分析以量化新的骨,残留的移植材料和软组织百分比.
主要成果:
- 8个月的愈合期 (CG) 与4个月 (TG) (20.02%) 相比,显著增加了新的骨形成 (28.22%).
- 在4个月后的组 (39.12%) 与8个月后的组 (31.65%) 相比,观察到更大的骨替代物再吸收.
- 组织学分析表明,在8个月后的组中,骨组织和有组织的原纤维更加成熟.
结论:
- 一个8个月的愈合期显著提高骨形成和成熟后上鼻增大用烧结牛骨移植.
- 较长的愈合间隔似乎优化了再生骨质的质量,可能改善植入物骨质整合.
- 研究结果表明,在这种情况下,延长愈合期超过4个月对骨再生有益.
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