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Updated: Feb 6, 2026
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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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红葡萄酒多在性牙周炎中的细胞和分子免疫调节潜力
R Ricci1, B M Pereira1, J D A Alvarado1
1Departamento de Odontologia Preventiva e Restauradora, Faculdade de Odontologia, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
概括
无酒精红葡萄酒 (DRW) 在巨细胞纤维细胞共同培养和大鼠牙炎模型中显示出抗炎作用. 然而,在研究中,这些好处并没有显著减少周围骨损失.
科学领域:
- 口腔生物学 口腔生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牙周炎 (AP) 涉及复杂的炎症过程.
- 红葡萄酒含有具有潜在抗炎功能的生物活性化合物.
- 处理酒精的红葡萄酒 (DRW) 对与AP相关的炎症的影响尚未完全理解.
研究的目的:
- 为了研究DRW对巨细胞 (MQ) - 牙周带纤维细胞 (PDLFs) 共同培养中的细胞因子概况的影响.
- 评估DRW对血液参数,炎症标志物,细胞因子表达和周周骨损失的影响.
主要方法:
- 诱导AP的MQ-PDLF和Wistar大鼠的共同培养被用DRW,红酒 (W) 或对照物 (DMEM/水) 治疗.
- 使用多重免疫试验分析了细胞因子概况.
- 小鼠接受了血液分析,放射学,qRT-PCR和组织测量分析.
主要成果:
- 在共同培养中,DRW降低了促炎细胞因子 (IL-6,TNF-α,IL-1β) 和增加了IL-10.
- 在大鼠中,DRW降低了单细胞数量,并在AP病变中调节了IL-1β和IL-10的表达.
- 在各组之间没有观察到血炎症/骨标志物或周围骨损失的显著差异.
结论:
- 在体外和体内,DRW表现出一种抗炎性特征.
- 在这个实验模型中,这些抗炎作用并没有转化为减少周围骨损失.
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