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类风湿性关节炎中的亚临床动脉样硬化:来自ELSA-巴西的病例队列分析
P F Estrada1, M R N Cavalcante1, I S Santos1
1Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.
概括
风湿性关节炎 (RA) 在8年内没有显示与心动脉内心介质厚度 (cIMT) 或心动脉斑块 (CAP) 的独立关联. 这项研究发现,与对照人群相比,RA患者的动脉样硬化进展风险没有增加.
科学领域:
- 心血管健康 心血管健康
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 风湿性关节炎 (RA) 是一种慢性炎症疾病,与心血管风险增加有关.
- 动脉内心介质厚度 (cIMT) 和动脉斑块 (CAP) 是亚临床动脉样硬化的标志物.
- 关于RA患者动脉样硬化进展的纵向数据有限.
研究的目的:
- 与对照组相比,评估RA患者中cIMT和CAP的流行,发病率和进展情况.
- 确定RA是否是动脉样硬化发展和进展的独立风险因素.
- 在8年的随访期内分析动脉样硬化标志物.
主要方法:
- 一个用ELSA-巴西队列数据进行的病例-队列分析.
- 带超声波用于测量基线和随访时的cIMT和CAP.
- 使用线性和逻辑回归模型,调整心血管风险因素.
主要成果:
- 在RA和基线cIMT,高cIMT或cIMT进展之间没有发现显著的关联.
- 在RA患者中观察到一种非显著的趋势,即增加cIMT发病率的风险更高.
- 与对照组相比,在RA患者中没有发现CAP流行,发病率或进展的显著关联.
结论:
- 这项研究发现,类风湿性关节炎和心动脉内膜介质厚度或心动脉斑块之间没有独立的关联.
- 在这个队列中,RA似乎不是亚临床动脉样硬化进展的独立预测因子.
- 可能需要进一步的研究来探索潜在的微妙关联或特定的子组.
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