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Updated: Feb 6, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Published on: May 22, 2014

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KEAP1/NRF2轴控制人体内皮细胞中LPS诱导的氧化应激,炎症酶激活和caspase-1活动

Alba Montero-Jodra1,2, Maria Jesús Estebán-Amo2,3, Silvia Patricia Fernández-Martínez2

  • 1Department of Surgery, University of Valladolid, Valladolid, Spain.

PloS one
|February 4, 2026
PubMed
概括

4-octyl itaconate (4-OI) 通过减少氧化应激,保护内皮细胞免受败血症引起的炎症. 这通过KEAP1/NRF2途径发生,抑制炎酶激活和线粒体ROS.

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