Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.8K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Depth Perception and Spatial Vision01:15

Depth Perception and Spatial Vision

2.0K
Depth perception is the ability to perceive objects three-dimensionally. It relies on two types of cues: binocular and monocular. Binocular cues depend on the combination of images from both eyes and how the eyes work together. Since the eyes are in slightly different positions, each eye captures a slightly different image. This disparity between images, known as binocular disparity, helps the brain interpret depth. When the brain compares these images, it determines the distance to an object.
2.0K
Directing Effect of Substituents: ortho–para-Directing Groups01:14

Directing Effect of Substituents: ortho–para-Directing Groups

8.5K
Ortho–para directors are substituent groups attached to the benzene ring and direct the addition of an electrophile to the positions ortho or para to the substituent. All electron-donating groups are considered ortho–para directors. They donate electrons to the ring and make the ring more electron-rich. The ring is therefore susceptible to the addition of electrophiles. Substituents such as amino, hydroxy, or alkoxy, containing lone pairs on the atom adjacent to the ring, donate...
8.5K
Directional Terms01:14

Directional Terms

16.8K
Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
16.8K
Directional Relays01:25

Directional Relays

620
Directional relays, essential for managing unidirectional fault currents, enhance the safety and efficiency of power systems. On power lines equipped with directional relays, faults downstream (to the right) of the current transformer typically cause the fault current to lag the bus voltage by approximately 90 degrees, known as the forward direction. In contrast, upstream (left-side) faults may result in the fault current leading the bus voltage by nearly 90 degrees, termed the reverse...
620

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Structured Schemas for Provenance-Rich, LLM-Assisted QSP Model Calibration.

bioRxiv : the preprint server for biology·2026
Same author

Asynchronous evolution of epithelium and stroma differentiates precursor lesions from pancreatic cancer.

Cancer discovery·2026
Same author

Rewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer.

bioRxiv : the preprint server for biology·2026
Same author

ISPAT-3D: Spatially Varying Conditional Volumetric Network Estimation for 3D Tumor Imaging.

bioRxiv : the preprint server for biology·2026
Same author

Mapping the Tumor Microenvironment with Integrative Single-Cell RNA Sequencing and Spatial Proteomics: Uncovering Mechanisms of Disease and Therapeutic Resistance.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

From Raw Data to Biological Insights: A Practical Guide for Spatial Transcriptomics Analysis in R and Python.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Another 10 years of PLOS Computational Biology: A data-driven reflection on trends in genomics research.

PLoS computational biology·2026
Same journal

Mobility data resolution needed to inform predictive models of spatial epidemic spread from mobile phone data.

PLoS computational biology·2026
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
查看所有相关文章

相关实验视频

Updated: Feb 6, 2026

Sandwich-like Microenvironments to Harness Cell/Material Interactions
06:50

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

8.0K

阴影:一个多层次的贝叶斯框架,用于模拟组织微环境中的定向空间相互作用.

Joel Eliason1, Michele Peruzzi2, Arvind Rao2,3,4,5

  • 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.

PLoS computational biology
|February 4, 2026
PubMed
概括
此摘要是机器生成的。

新的空间分析框架Shade模拟了组织中的不对称细胞相互作用. 它通过整合跨患者和队列的数据来改善对癌症等复杂疾病的空间模式的理解.

更多相关视频

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

15.0K
Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip
08:15

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

3.4K

相关实验视频

Last Updated: Feb 6, 2026

Sandwich-like Microenvironments to Harness Cell/Material Interactions
06:50

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

8.0K
MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

15.0K
Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip
08:15

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

3.4K

科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 空间奥米克斯 空间奥米克斯

背景情况:

  • 了解组织微环境中的细胞-细胞空间相互作用对于免疫学,瘤学和发育生物学至关重要.
  • 目前的空间分析方法往往缺乏解释性和统计能力,因为对称性假设和孤立患者数据分析.

研究的目的:

  • 介绍SHADE (通过定向估计的空间等级不对称),这是一个新的贝叶斯框架,用于建模不对称的空间相互作用.
  • 通过整合跨多个尺度和队列的数据来增强空间分析的生物解释性和统计能力.

主要方法:

  • 开发了一个多层次的贝叶斯框架 (SHADE) 来建模不对称和定向的细胞-细胞关联.
  • 利用光滑的空间交互曲线 (SIC) 来量化方向特定的交互.
  • 跨组织部分,患者和队列的综合数据,以进行可靠的分析.

主要成果:

  • 与模拟研究中的现有方法相比,SHADE表现出卓越的准确性,稳定性和可解释性.
  • 应用于结直肠癌数据,SHADE量化了定向空间模式,同时考虑到组织结构和患者异质性.
  • 确定了分子亚型内的局部微环境结构在患者水平上的显著变化.

结论:

  • SHADE为分析生物组织中复杂的空间关系提供了一个强大的新工具.
  • 该框架显示,局部组织微环境表现出相当大的患者特异性,即使在定义的分子亚型内也是如此.
  • 这种方法促进了对癌症等疾病的空间组织的理解.