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Updated: Feb 6, 2026

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在人体GLP1RA316T变异的体内功能概况和结构特征

Liliane El Eid1, Yusman Manchanda1, Gregory Austin1

  • 1Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Science advances
|February 4, 2026
PubMed
概括

GLP-1受体A316T变体通过改变基底受体活性,提供对2型糖尿病和肥胖的保护. 然而,这种变异会减弱对GLP-1受体激素治疗的反应.

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