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化学抗原受体T细胞对抗IGHV4-34 B细胞受体,专门消除瘤和自身免疫B细胞

Ivan J Cohen1,2,3, Audrey C Bochi-Layec1,2,3, Jean Lemoine1,2,3

  • 1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science translational medicine
|February 4, 2026
PubMed
概括

研究人员开发了针对B细胞受体 (BcR) IGHV4-34.4的新型仿真抗原受体 (CAR) T细胞. 这些CART4-34细胞在治疗B细胞恶性瘤和全身性红斑狼 (SLE) 方面表现有前途,通过专门向致病性B细胞.

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