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Updated: Feb 6, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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发现SKP2-招募PROTACs用于目标蛋白降解的发现

Guanjun Dong1,2,3, Aima Huang1,2,3, Ziqing Zhao1,2,3

  • 1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 4, 2026
PubMed
概括

这项研究表明,S相激酶相关蛋白2 (SKP2) 可以用新型的PROTACs用于向蛋白质降解 (TPD). 这些SKP2招募分子有效降解BRD4和雄激素受体 (AR) 等标蛋白.

关键词:
这就是BRD4D.E3 结合酶的使用这就是PROTAC.在SKP2中,SKP2是SKP2.有针对性的蛋白质降解降解.

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