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上腺雄激素作为预测生长特征的预测者在早发性潮

Mehmet Eltan¹, Zehra Yavas Abali¹, Aylin Tugba Canbaz¹

¹Marmara University, School of Medicine, Department of Pediatric Endocrinology and Diabetes, 34854, Istanbul, Turkey.

European journal of endocrinology

|February 4, 2026

概括

在早熟性青春期 (PP) 的女孩中,上腺的雄激素不能预测成长结果. 这表明孤立的PP是良性的,在排除其他原因后,需要采取保守的管理方法.

科学领域:

儿科内分泌学儿科内分泌学
青少年医学青少年医学
内分泌学在内分泌学.

背景情况:

过早性性 pubarche (PP) 是阴毛,身体气味或的早期发病,通常与升高的脱水氨硫酸 (DHEA-S) 相关.
新兴研究表明,11-氧化上腺 (11OHA4,11OHT) 可能更准确地反映雄激素活性.

研究的目的:

评估上腺的预测价值增长特征的女孩早产 (PP).

主要方法:

一项前性研究,涉及53名女孩与隔离PP和36对照.
使用LC-MS/MS的量化血上腺激素 (DHEA,DHEA-S,A4,安德罗斯特,11OHA4,11OHT) 使用LC-MS/MS.
在2.7年的随访期间评估了人类测量和临床特征.

主要成果:

与对照组相比,患有PP的女孩的身高,BMI-SDS,DHEA,DHEA-S,A4,安德罗斯特和17OH-孕醇水平较高.
两组之间没有发现11OHA4和11OHT度的显著差异.
上腺的雄激素水平与身高,校正的身高或生长速度没有相关性.

结论:

孤立的异常性早产性 pubarche 可能是一种良性发育变体.
上腺的雄激素似乎不会对这些患者的线性生长产生负面影响.
在排除了病理条件后,建议对孤立的PP采取保守的管理策略.

关键词:

这种11-oxyandrogens是11-oxyandrogens.11β-基二二氨基.11β-基测试氨酸.在DHEA-S中使用.过早的青春期 - - 过早的青春期增长的增长增长的增长增长的增长.

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