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关于生物标志物测试模式和对mNSCLC治疗选择影响的真实世界见解

Amy Stanford¹, Shawn Boykin¹, Karishma Desai²

¹Value Strategy & Evidence, US Market Access, AstraZeneca, Wilmington, DE.

The American journal of managed care

|February 4, 2026

概括

大多数转移性非小细胞肺癌患者错过了综合生物标志物测试,阻碍了精确治疗. 检测和治疗机会的差异需要紧急关注,以改善公平的癌症护理.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断
医疗保健服务研究医疗服务研究

背景情况:

生物标志物测试对于定制转移性非小细胞肺癌 (mNSCLC) 的第一线治疗至关重要.
在mNSCLC中的现实世界生物标志物测试模式不一致,可能导致结果差异.

研究的目的:

在新诊断的mNSCLC患者中调查现实世界生物标志物测试模式.
分析测试,一线治疗选择和社会人口统计因素之间的关联.

主要方法:

在2019年1月至2022年7月期间诊断的5611名mNSCLC患者的回顾性分析.
基于生物标志物测试的患者分类:没有,仅IHC,<5基因加IHC,或≥5基因加IHC.
多变量分析以评估测试,治疗和健康的社会决定因素之间的关联.

主要成果:

超过60%的患者没有接受符合指南的生物标志物测试.
综合测试与增加的向疗法/免疫疗法使用和减少的化疗使用相关.
测试和治疗模式因社会经济地位,种族/种族,保险和地区而异.

结论:

大多数mNSCLC患者缺乏全面的生物标志物测试,限制了精确治疗的机会.
测试和治疗的显著差异凸显了改善分子诊断和支付者支持的必要性.
将检测和治疗与国家指导方针相协调对于公平的癌症护理和改善患者结果至关重要.

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