:引用完整性和科学监督的教训
Youngwoo Cho1, Thomas Chen1,2,3, Mark J Ratain1,2,3
1Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL.
JCO oncology practice
|February 4, 2026
概括
尽管面临挑战,但许多研究继续引用关于硫氨酸S-甲基转移酶 (TPMT) 和西斯胺的耳毒性有缺陷的发现. 这凸显了对基础文献的批判性参与和改善出版后监督的需要.
科学领域:
- 药物基因组学 药物基因组学
- 临床毒理学 临床毒理学
- 科学文献分析 科学文献分析
背景情况:
- 2009年自然遗传学文章由罗斯等人撰写. 与TPMT与西斯胺诱导的耳毒性有关.
- 这项基础研究的发现随着时间的推移,面临着重大挑战和批评.
研究的目的:
- 评估2009年罗斯等人继续引用的情况. 文章. 这篇文章.
- 评估科学文献中关于TPMT和西斯的耳毒性有争议的发现如何持续存在.
主要方法:
- 从2009年到2025年,对378个谷歌学者引用的系统审查.
- 对214个PubMed索引手稿进行选,以对引用细微差别进行分类 (积极,消极/混合).
- 两位研究人员对引用上下文进行了独立审查,差异通过共识解决.
主要成果:
- 大多数引用都以有利或不批判的方式呈现了2009年的研究结果.
- 这种模式甚至在2015年FDA对西斯的标签修订后也持续存在,承认了缺陷.
- 引用的比例较小,承认有矛盾的证据或质疑研究的有效性.
结论:
- 许多作者继续引用2009年的研究,但没有承认其局限性或挑战.
- 需要加强出版后监督和更透明的编辑实践.
- 作者必须批判性地参与基础文献,以确保基于证据的临床和研究叙述.
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