在儿科晚期癌症中整合电子患者报告结果和息护理:PediQUEST响应多站点随机控制试验
Veronica Dussel1, Liliana Orellana2, Maria L Requena3
1Pediatric Palliative Care Research and Innovation Lab, MassGeneral for Children, Boston, MA.
概括
将电子患者报告结果与儿科息护理相结合,改善了晚期癌症儿童的健康相关生活质量. 需要进一步的实施策略来最大限度地提高收益.
科学领域:
- 儿科瘤学 儿科瘤学
- 抚慰性护理是一种缓解性护理.
- 与健康相关的生活质量 (HRQOL)
背景情况:
- 晚期癌症显著影响儿童的HRQOL.
- 整合技术和专业护理可能会改善结果.
研究的目的:
- 评估将电子患者报告结果 (ePRO) 反与专门儿科息护理 (SPPC) 咨询相结合是否可以改善晚期癌症儿童的HRQOL.
- 评估PediQUEST对儿科瘤症状经验 (PQ反应) 随机对照试验 (RCT) 的反应.
主要方法:
- 一个多中心的,开放标签的RCT,涉及2岁以上的晚期癌症儿童.
- 参与者被随机分配到PQ响应或常规护理16周.
- 每周对父母和孩子 (5岁以上) 进行HRQOL和症状调查.
主要成果:
- 在PQ响应组的家长报告了儿童HRQOL的更大改善 (PedsQL总得分:3.45分,P=.023).
- 物理HRQOL得分显著改善,但效应并不总是超过临床重要差异最小值 (MCID).
- 心理社会HRQOL或症状得分没有显著改善;然而,灵敏度分析表明,一些症状得分的改善超过了MCID.
结论:
- 整合ePRO反和SPPC显示了对儿科晚期癌症护理的潜在好处.
- 需要加强实施策略,以优化这些联合干预措施的临床影响.
- 这项研究强调了需要量身定制的方法来改善儿科瘤患者的HRQOL.
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