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Updated: Feb 6, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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Published on: February 28, 2021

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在BRCA1和BRCA2病原型变体载体中,具有或没有降低风险的乳房切除术的生存结果

Ashu Gandhi1,2,3, Sacha J Howell1,2,3,4, Elaine F Harkness5

  • 1Division of Cancer Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
|February 4, 2026
PubMed
概括

与监测相比,双边降低风险的乳腺切除显著降低了BRCA1/2载体的乳腺癌发病率. 然而,两组的整体存活率和乳腺癌特异性存活率是相似的.

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