排名意识的多个实例学习对组织病理学幻灯片分类:开发和验证研究研究
Ho Heon Kim1,2, Gisu Hwang1, Won Chan Jeong1
1AI R&D Center, Seegene Medical Foundation, Seoul, Republic of Korea.
JMIR medical informatics
|February 4, 2026
概括
排名诱导,一种新的多实例学习 (MIL) 框架,有效地使用部分专家注释来改善数字病理学的幻灯片级分类. 这种方法在具有有限或粗略注释的现实场景中表现出稳健性.
科学领域:
- 数字病理学数字病理学
- 计算病理学计算病理学
- 机器学习在医学中的应用
背景情况:
- 多重实例学习 (MIL) 是数字病理学的幻灯片级分类的一个关键技术.
- 当前的MIL方法往往不能有效地利用部分专家注释.
- 专家的注释,即使是部分的,也可以显著提高监督学习模型.
研究的目的:
- 开发和评估一个排名意识的MIL框架,名为排名诱导.
- 将部分专家注释集成到MIL中,以改善幻灯片级分类.
- 在现实的注释约束下评估框架的性能.
主要方法:
- 开发了排名诱导,一种利用对对排名损失的MIL方法,灵感来自Rank.Net.
- 该框架通过更重视注释区域来优先考虑诊断相关的贴片.
- 在各种注释场景下对Camelyon16,DigestPath2019和SMF-stomach数据集进行评估.
主要成果:
- 排名引入获得了高的AUROC分数:0.839 (Camelyon16),0.995 (DigestPath2019) 和0.875 (SMF-stomach). 在这个过程中,我们可以获得高的AUROC分数.
- 该模型在低数据模式中表现出稳定性,在训练数据减少的情况下保持0.761 AUROC.
- 只有20%的稀疏的幻灯片级注释才能达到接近和的性能.
结论:
- 通过基于排名的监督整合专家注释,可以提高基于MIL的分类性能.
- 排名诱导证明在数字病理学应用中具有有限,粗略或稀疏注释的实用性和稳健性.
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