程序前系统性免疫炎症指数预测了导管切除后心房的复发:系统性审查和元分析
Bingshan Zhang1, Shourong Lu2, Zhehao Yin1
1Department of Geriatrics, The Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi, China.
Biomolecules & biomedicine
|February 4, 2026
概括
术前系统性免疫炎症指数 (SII) 的升高显著增加了导管切除后心房 (AF) 复发的风险. 这种炎症标记可能有助于预测切除后的结果.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 炎症与心房动 (AF) 病理生理学和消化后复发有关.
- 由中性粒细胞,淋巴细胞和血小板数量得出的全身免疫炎症指数 (SII) 是一种潜在的炎症生物标志物.
研究的目的:
- 为了评估在导管切除后手术前SII和AF复发之间的关联.
- 通过元分析综合现有观察性研究的证据.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Wanfang,CNKI) 进行全面的文献搜索.
- 纳入了10项纵向观察性研究,包括4045名接受射频或冷却气球移除的患者.
- 使用随机效应模型进行元分析,以汇总AF复发风险比率 (RRs).
主要成果:
- 高度的手术前SII与增加的AF复发风险显著相关 (RR = 2.32).
- 关联在敏感性分析中保持强,并在各种子组中保持一致.
- 每增加100个单位的SII与更高的复发风险相关 (RR = 1.09).
结论:
- 升高的手术前SII是导管切除后AF复发的重要预测因素.
- SII可以作为评估AF患者炎症状况的辅助生物标志物.
- 需要进一步的前性研究来验证.
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