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Updated: Feb 6, 2026

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AlphaMissense的病原性得分预测了免疫治疗的反应,并提高了瘤突变负担的预测能力

David Adeleke1, Adewale Oluwaseun Fadaka2, Nicole Remaliah Samantha Sibuyi2

  • 1Genomics, Phenomics & Bioinformatics Program, Department of Computer Science, North Dakota State University, Fargo, ND 58102, USA.

Translational oncology
|February 4, 2026
PubMed
概括

结合突变数量和致病性的一种新生物标志物AlphaTMB,可以更好地预测患者对免疫治疗的反应,而不仅仅是瘤突变负担 (TMB). 这种人工智能驱动的方法增强了个性化癌症治疗的患者分层.

关键词:
阿尔法Missense的意思是错误的意思阿尔法TMBB是什么意思免疫检查点抑制剂 (ICI)免疫疗法生物标志物新抗原负载的新抗原负载.在癌症患者的生存预测.瘤突变负担 (TMB) 是指瘤突变负担.

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