使用长效FSH试管婴儿试管婴儿协议的低卵巢储备患者中孕激素升高的风险:一种随机对照试验
Enrico Papaleo1, Antonio Quartucci1, Mara Zanirato1
1Obstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Reproductive biomedicine online
|February 4, 2026
概括
一个新的卵巢刺激方案使用 corifollitropin alfa (CFA) 显著减少过早的孕激素升高 (PPE) 在低卵巢储备的妇女. 这种方法还提高了新鲜胚胎移植率,提高了这一群体的试管婴儿成功率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 过早的孕激素升高 (PPE) 是试管婴儿的一个重大挑战,可能会降低成功率,特别是在卵巢储备较低的女性中.
- 优化卵巢刺激协议对于改善不良反应者的试管婴儿结果至关重要.
- 当前的协议可能无法充分减轻这种患者群体中PPE的风险.
研究的目的:
- 评估长效刺激方案与 corifollitropin alfa (CFA) 随后每日低剂量重组FSH (r-FSH) 是否降低过早孕激素升高 (PPE) 的风险.
- 为了比较这一方案与每日高剂量r-FSH在低卵巢储备的妇女.
- 评估对IVF关键结果的影响,例如卵细胞检索和胚胎移植.
主要方法:
- 一项随机对照试验,涉及110名符合卵巢反应不良的博洛尼亚标准的患者.
- 干预组:长期作用的CFA,然后从第8天开始每天150 IUr-FSH.
- 对照组:每天300 IUr-FSH. 主要结局:在hCG触发时,孕激素≥1.1ng/ml的患者比例.
主要成果:
- 与对照组 (22.2%) 相比,CFA组的PPE率 (3.6%) 显著降低,赔率降低了89%.
- 在CFA组 (65%) 与对照组 (44%) 相比,新鲜胚胎移植更可行.
- 还分析了诸如卵细胞检索和受精率之类的二次结果.
结论:
- 长期作用的CFA加上每天150 IUr-FSH显著降低了患有低卵巢储备的妇女的PPE风险.
- 这种刺激策略提高了新鲜胚胎移植的可行性,可能改善整体体IVF成功.
- 这些发现表明,一种有利的方法来管理不良响应者和减轻个人防护设备.
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