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血清25-氧维生素D度,睡眠特征和发生痴呆症的风险

Jiao-Jiao Ren¹, Zhi-Hao Li², Wen-Fang Zhong²

¹School of Health Management, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong Province, 510000, China; School of Public Health, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong Province, 510000, China.

|February 4, 2026

概括

较高的维生素D水平与较低的痴呆风险有关. 这种关联,特别是在血管痴呆症中,受到睡眠模式和白天嗜睡的影响.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
流行病学流行病学

背景情况:

血清25-基维生素D (25(OH) D) 水平与痴呆症风险有着不一致的关联.
维生素D的新陈代谢可能与睡眠特征有关.
以前的研究表明,维生素D,睡眠和认知能力下降之间存在复杂的关系.

研究的目的:

为了研究血清25(OH) D度与所有原因痴呆症,阿尔茨海默病和血管痴呆症的风险之间的关联.
为了确定睡眠特征和模式是否会改变血清25(OH) D和痴呆风险之间的关系.

主要方法:

一项基于人口的前性队列研究,涉及366,160名参与者.
测量血清25 (((OH) D度的方法.
评估睡眠特征 (持续时间,时间型,失眠,打,白天嗜睡),以确定睡眠模式.
利用多变量调整的考克斯比例危险回归模型来分析关联和相互作用.

主要成果:

较高的血清25(OH) D度与所有原因痴呆症,阿尔茨海默病和血管痴呆症的风险降低有关.
在血清25(OH) D和睡眠模式之间观察到与血管痴呆风险相关的显著相互作用 (P=0.04).
具体来说,血清25(OH) D与白天嗜睡与血管痴呆风险相关的相互作用 (P=0.03),在白天嗜睡较少的人群中具有更大的保护作用.

结论:

血清25(OH) D度显示与所有原因痴呆症,阿尔茨海默病和血管痴呆症风险的反向关联.
睡眠特征,特别是白天的嗜睡,可能会调节维生素D对血管痴呆风险的保护作用.

关键词:

痴呆症是一种痴呆症.血清中的25-基维生素D.睡眠睡眠睡眠睡眠血管痴呆症是一种精神疾病.维生素D 维生素D是一种维生素.

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