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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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在缺氧下USP21介导的SMARCB1稳定可能会影响HCC中的瘤进展和免疫反应

Minho Kim1, Myoung Jun Kim1, Sung Kyung Choi1

  • 1School of Medicine, Konkuk University, Chungju, 27478, Republic of Korea.

Biochemical and biophysical research communications
|February 4, 2026
PubMed
概括

在低氧状态下,USP21在肝细胞癌 (HCC) 中稳定SMARCB1,促进瘤生长和免疫抑制. 针对这个USP21-SMARCB1轴,为HCC治疗提供了一个新的治疗策略.

关键词:
肝细胞癌是肝细胞癌.氧气过低是因为缺氧.免疫检查站检查站干扰素-γ 干扰素-γ 的作用在SMARCB1中,USP21 美国21

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