可调的凝涂层生物合成金纳米三角形:通过按需可见-NIR LED激活来实现热塑性性能和体外治疗潜力

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Updated: Feb 6, 2026

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Template Directed Synthesis of Plasmonic Gold Nanotubes with Tunable IR Absorbance

Published on: April 1, 2013

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Oana Raducu¹, Raluca Borlan², Alexandru Holca¹

¹Biomolecular Physics Department, Faculty of Physics, Babeș-Bolyai University, 1 M. Kogălniceanu Str, Cluj-Napoca 400084, Romania; Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute in Bio-Nano-Sciences, Babeș-Bolyai University, 42 T. Laurian Str, Cluj-Napoca 400271, Romania.

Colloids and surfaces. B, Biointerfaces

|February 4, 2026

概括

本研究介绍了一种绿色方法,用于使用凝制造金纳米三角形 (AuNT). 这些AuNT显示了在癌症治疗中潜在的LED驱动光热疗法的高效光热转换.

科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

金纳米三角形 (AuNTs) 为生物医学应用提供独特的光学特性.
目前的合成方法通常涉及强化学品和表面活性剂.
用光热疗法向特定的癌细胞需要具有可调节性质的生物相容纳米材料.

研究的目的:

开发一种绿色,无表面活性剂的生物合成方法,用于使用凝的AuNTs.
描述用于NIR-II窗口应用的AuNTs可调的局部化表面等离子体共振 (LSPR).
评估凝稳定AuNTs在潜在的光热疗法中的热质表现和光热细胞毒性.

主要方法:

使用凝作为封闭剂和甲酸作为减少剂的AuNTs的生物合成.
描述AuNT的大小,形态和LSPR特性.
使用LED和激光照射对光热转换效率的评估.
在乳腺癌细胞系中的体外细胞毒性测定和细胞吸收研究 (MDA-MB-231和MCF-7).

主要成果:

凝成功调节了AuNTs的合成,可调节的LSPR在880-1090nm之间.
高光热转换效率 (高达~65%) 在NIR范围内通过LED辐射实现.
凝稳定的AuNTs表现出可以忽略不计的内在细胞毒性,并被癌细胞吸收.
在850nm辐射后,在MCF-7细胞中观察到显著的光热细胞毒性 (~ 47%).

结论:

凝生物合成的AuNT是高效,生物相容的光热纳米传感器.
使用这些AuNTs的LED驱动光热疗法对癌症治疗有希望.
可调节的LSPR和生物相容性使这些AuNT适合临床翻译.

关键词:

通过凝介导的合成.黄金纳米三角形是什么在体外细胞毒性.在LED照射照射中.在NIR-II地区,NIR-II地区是NIR-II区域.光热疗法是一种光热疗法.

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