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Updated: Feb 6, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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三甲基锁-2Cl (TML-2Cl):一种自我循环的适配器,用于抗体-药物合物的分子释放

Xuzhuo Li1, Lizhe Bai1, Xiaomei Li1

  • 1Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, PR China.

European journal of medicinal chemistry
|February 4, 2026
PubMed
概括

研究人员开发了一种新型的三甲基锁 (TML) 系统,用于抗体-药物联合体 (ADC). 这种TML系统,特别是TML-2Cl,增强了有效载荷释放和瘤抑制,扩大了ADC开发的可能性.

关键词:
氨基胺是什么? 氨基胺是什么?抗体与药物的结合物.药物交付是药物交付的过程.埃克萨特是一种.三甲基锁的三甲基锁.

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